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Developmental Biology - Pregnancy
What a mother gives to her baby besides genes
Maternal contributions to the health of her baby are the focus of a special issue form the Teratology Society...
Beginning in the womb, a mother transmits a slew of molecules, microbes and cells to her developing baby — transmissions that regulate the growth of the baby's brain, heart and immune system. Impairment of these molecules increases the risk for birth defects and/or diseases as diverse as food allergies and schizophrenia. All of these topics are examined in a special issue of Birth Defects Research Connections published by the Teratology Society along with John Wiley & Sons.
"Interactions between the maternal environment and offspring genes are hyper-complex, but studying them may suggest incredible opportunities to prevent diseases that are notoriously hard to treat after the fact. The reviews in this issue present are the latest on what scientists and physicians have learned about maternal influences on the baby in utero."
Patrick Jay, MD PhD, Professor of Pediatrics, Washington University, St. Louis School of Medicine, and co-editor of the special Birth Defects Research issue.
"Simply put - we're at the tip of the iceberg in understanding how the gestational environment established by the mother affects her child's health from birth to adulthood. If an ounce of prevention is worth a pound of cure for one disease, targeting adverse maternal effects in the womb could be worth a ton for future public health."
Michiko Watanabe PhD, Professor of Pediatrics, Case Western Reserve University School of Medicine, and co-editor of the special Birth Defects Research issue.
The special issue includes these following articles:
Inherited Nongenetic Influences on the Gut Microbiome and Immune System, by Knoop et al. of the Washington University in St. Louis School of Medicine (DOI: 10.1002/bdr2.1436).
Maternal hyperglycemia and fetal cardiac development: Clinical impact underlying mechanisms, by Basu and Garg of Ohio State University, Columbus (DOI: 10.1002/bdr2.1435).
Maternal Immune Activation, Central Nervous System Development and Behavioral Phenotypes, by Minakova and Warner of the Washington University in St. Louis School of Medicine (DOI: 10.1002/bdr2.1416).
Oxygen and Lack of Oxygen in Fetal and Placental Development, Feto-placental Coupling and Congenital Heart Defects, by Olive et al. of the Universitat Autònoma de Barcelona, Barcelona, Spain (DOI: 10.1002/bdr2.1430).
Uterine Natural Killer Cells: To Protect and to Nurture, by Sojka et al. of the Washington University in St. Louis School of Medicine (DOI: 10.1002/bdr2.1419).
Adverse maternal environment leads to cardiac fibrosis in adult male mice, by Spearman et al. of the Children's Hospital of Wisconsin (DOI: 10.1002/bdr2.1428).
Abstract
The full special issue is freely available for 60 days after which time Teratology Society members who have a subscription to BDR may access the full articles via the Teratology website using your member login information.
Individuals without a subscription may peruse the TOC, abstracts, and any freely available papers and special issues, by visiting the journal on the Wiley website, by clicking HERE.
Editor
Michel Vekemans.
Acknowledgements
About the Teratology Society
The Teratology Society is an international and multidisciplinary group of scientists including researchers, clinicians, epidemiologists, and public health professionals from academia, government and industry who study birth defects, reproduction, and disorders of developmental origin. The Teratology Society is made up of nearly 700 members worldwide specializing in a variety of disciplines, including developmental biology and toxicology, reproduction and endocrinology, epidemiology, cell and molecular biology, nutritional biochemistry, and genetics as well as the clinical disciplines of prenatal medicine, pediatrics, obstetrics, neonatology, medical genetics, and teratogen risk counseling. Scientists interested in membership in the Teratology Society are encouraged to visit http://www.teratology.org.
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Jan 4, 2019 Fetal Timeline Maternal Timeline News News Archive
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